TABLE 1 .
List of C. neoformans genes investigated in this study and their orthologs in S. cerevisiaea
| S. cerevisiae gene | S. cerevisiae gene product description | C. neoformans locus tag (CNAG no.) | C. neoformans gene designation | C. neoformans gene product description (reference) |
|---|---|---|---|---|
| PHO4 | Basic helix-loop-helix transcription factor; activates transcription cooperatively with Pho2p in response to phosphate limitation | CNAG_06751 | PHO4/HLH3 | Phosphate-responsive transcription factor (7) |
| PHO84 | High-affinity inorganic phosphate (Pi) transporter | CNAG_02777 | PHO84 | Phosphate/H+ symporter (8) |
| CNAG_05459 | PHO840 | Pi transporter A-1 (8) | ||
| PHO89 | Plasma membrane Na+/Pi cotransporter | CNAG_05075 | PHO89 | Sodium-dependent phosphate transporter (8) |
| PHO5 | Phosphate-repressible acid phosphatase | CNAG_02944 | APH1 | Secreted and vacuolar acid phosphatase (9) |
| CNAG_06967 | APH2 | Phytase | ||
| CNAG_02681 | APH3 | Phytase | ||
| CNAG_06115 | APH4 | Acid phosphatase | ||
| VTC4 | Vacuolar transporter chaperone | CNAG_01263 | VTC4 | Vacuolar transporter chaperone 4 (8) |
| NA | CNAG_02353 | BTA1 | Betaine lipid (DGTS) synthase | |
| PHO81 | Cyclin-dependent kinase inhibitor | CNAG_02541 | PHO81 | Cyclin-dependent protein kinase inhibitor (7) |
| GDE1 | Glycerophosphocholine phosphodiesterase | CNAG_06614 | GDE2 | Glycerophosphodiesterase |
a
NA, not applicable; DGTS, diacylglycerol-trimethylhomoserine.