Table 2.

Antitubercular activities of saturated acid and ester MEPicides

Cmpd No.	R1	R2	R3	M. tuberculosis MIC (µg/mL)*
INH	N/A	N/A	N/A	0.01
1 (Fos)	H	H	H/Na	>500
2 (FR900098)	H	CH3	H/Na	>500
3	H	CH3	CH2OCOtBu	50–100 (62.5)
8e	H	Ph	H/Na	≥200
8h	H	(CH2)3Ph	H/Na	>200
7h	H	(CH2)3Ph	CH2CH3	200
12	H	(CH2)3Ph	CH2OCOtBu	150
8d	H	(CH2)2cyclohexyl	H/Na	>200 (25)
7d	H	(CH2)2cyclohexyl	CH2CH3	>200 (37)
8l	H	CH2O(4-Cl)Ph	H/Na	>200 (25)
16d	(4-ipr)Bn	CH3	H/Na	200 (25)
17	(4-ipr)Bn	CH3	CH2OCOtBu	12.5 (6.25–12.5)
16k	CH2-4-(1,1’-biphenyl)	CH3	H/Na	25–50
15k	CH2-4-(1,1’-biphenyl)	CH3	CH2CH3	200 (100)
19	CH2-4-(1,1’-biphenyl)	CH3	CH2OCOtBu	12.5 (3.13–6.25)
16p	CH2-4-(4’-ipr)-1,1’-biphenyl	CH3	H/Na	100 (6.25–12.5)
16h	(CH2)4Ph	CH3	H/Na	≥200
15h	(CH2)4Ph	CH3	CH2CH3	100–200
21	(CH2)4Ph	CH3	CH2OCOPh	25
18	(CH2)4Ph	CH3	CH2OCOtBu	12.5 (6.25–12.5)
16j	CH2-(2-naphthyl)	CH3	H/Na	≥200
15j	CH2-(2-naphthyl)	CH3	CH2CH3	200 (100)
20	CH2-(2-naphthyl)	CH3	CH2OCOtBu	18.75 (4.7)

^*Data using 7H9 media. When different, MIC in GAST-Fe media is given in parentheses.