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. Author manuscript; available in PMC: 2017 Jan 25.
Published in final edited form as: Dev Biol. 2016 Nov 29;421(2):219–232. doi: 10.1016/j.ydbio.2016.11.016

Fig. 7.

Fig. 7

Lower jaw gene expression pattern of chondrocyte and bone markers in wls, wnt9a, wnt5b and gpc4 mutants. Whole-mount RNA in situ hybridization of chondrocyte differentiation markers; sox9a (A–E) and chondrocyte matrix; col2a1 (F–J). Hypertrophic chondrocyte marker; col10a1a (K–O), Bone and tendon marker; col1a2 (P–T), osteoblastic progenitor marker; runx2a (U–Y) and joint marker; bapx1 (Z–AD). (K′–L′) 40X image focused on ceratohyal (ch; left) and both cleithrum and ceratobranchial 5 (cl, cb; right). (P′–T′) 40X images focused on dentary (de; left) and ceratohyal (right). Apparent increase in sox9a, runx2a expression pattern in wls −/− with concomitant loss of col10a1a. Black arrowhead points to the position of Meckel’s cartilage. Scale=50 μm..