Table 2.
Clinical outcomes associated with thyroid hormone treatment
| Adverse outcomes* | No (%) events | Odds ratio (95% CI) | P value† | |||
|---|---|---|---|---|---|---|
| Thyroid hormone treatment (n=843) | No thyroid hormone treatment (n=4562) | Unadjusted | Adjusted | |||
| Pregnancy loss‡ | 89 (10.6) | 614 (13.5) | 0.76 (0.60 to 0.96) | 0.62 (0.48 to 0.82) | <0.01 | |
| Preterm delivery | 60 (7.1) | 236 (5.2) | 1.41 (1.05 to 1.88) | 1.60 (1.14 to 2.24) | 0.01 | |
| Preterm labor | 111 (13.2) | 569 (12.5) | 1.08 (0.87 to 1.34) | 1.14 (0.89 to 1.46) | 0.29 | |
| Premature rupture of membranes | 42 (5.0) | 220 (4.8) | 1.04 (0.74 to 1.45) | 0.97 (0.66 to 1.42) | 0.87 | |
| Placental abruption | 7 (0.8) | 36 (0.8) | 1.05 (0.47 to 2.37) | 1.60 (0.65 to 3.93) | 0.30 | |
| Gestational diabetes | 101 (12.0) | 401 (8.8) | 1.41 (1.12 to 1.78) | 1.37 (1.05 to 1.79) | 0.02 | |
| Gestational hypertension§ | 49 (5.8) | 221 (4.8) | 1.24 (0.90 to 1.70) | 1.27 (0.88 to 1.82) | 0.21 | |
| Pre-eclampsia§ | 46 (5.5) | 177 (3.9) | 1.43 (1.03 to 2.00) | 1.61 (1.10 to 2.37) | 0.01 | |
| Poor fetal growth | 78 (9.3) | 397 (8.7) | 1.07 (0.83 to 1.38) | 1.12 (0.84 to 1.50) | 0.45 | |
| Tachycardia | 18 (2.1) | 90 (2.0) | 1.08 (0.65 to 1.81) | 1.77 (1.00 to 3.11) | 0.05 | |
*Adjusted for age and thyroid stimulating hormone (TSH) concentration as continuous variables and for ethnicity, income, Charlson index, hypertension, obesity, and history of thyroid disease.
†For adjusted outcomes.
‡Additionally adjusted for history of pregnancy loss.
§Adjusted for age and TSH concentration as continuous variables and for ethnicity, income, Charlson index, obesity, and history of thyroid disease.