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. Author manuscript; available in PMC: 2018 Jan 25.
Published in final edited form as: J Am Chem Soc. 2017 Jan 12;139(3):1049–1052. doi: 10.1021/jacs.6b11336

Table 2.

Asymmetric Cyclopropanation of Different Olefins with Tosylhydrazone 1b Catalyzed by [Co(P3)]a

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a

Carried out with 1b (0.1 mmol) and 2x (1.5 equiv.) in the presence of Cs2CO3 (2 equiv.) in methanol (0.6 mL); isolated yields; dr was determined by 1H NMR; ee of the major trans diastereomer was determined by chiral HPLC.

b

Performed on 1.0 mmol scale.

c

Absolute configuration was determined by X-ray as (1S, 2S).

d

5 mol % [Co(P3)].

e

5.0 equiv. 2q.