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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Ann Neurol. 2017 Jan;81(1):79–92. doi: 10.1002/ana.24833

Table 3.

Retrospective neuropathological validation of RT QuIC.

Neuropathological Assesment
CSF Unit Prion
Negative
Prion
Positive
sCJD gCJD
RT QuIC n 67 126 111 15
Specificity % 98.5 98.5 98.5
Sensitivity % 92.1 91.9 93.3
PPV % 99.1 99.0 93.3
NPV % 86.8 88.0 98.5
14-3-3
Specificity % 62.7 62.7 62.7
Sensitivity % 81.7 82.9 73.3
PPV % 81.1 79.3 31.4
NPV % 82.4 87.5 93.3
tTau≥1150 pg/ml
Specificity % 46.3 46.3 46.3
Sensitivity % 90.5 91.0 86.7
PPV % 76.0 73.7 26.5
NPV % 72.1 75.6 93.9
HHS Vulnerability Disclosure