Table 5.
Prospective neuropathological validation of CSF RT-QuIC. All statistical conclusions are based on the separate evaluation of each CSF test. The brackets indicate weak CSF data statistics due to the limited number gCJD cases.
| Neuropathological Assessment | ||||||
|---|---|---|---|---|---|---|
| CSF | Unit | Prion Negative |
Prion Positive |
sCJD | gCJD | |
| RT QuIC | n | 14 | 65 | 63 | 2 | |
| Specificity | % | 100.0 | 100.0 | [100.0] | ||
| Sensitivity | % | 95.4 | 95.2 | [100.0] | ||
| PPV | % | 100.0 | 100.0 | [100.0] | ||
| NPV | % | 82.4 | 82.4 | [100.0] | ||
| 14-3-3 | ||||||
| Specificity | % | 42.9 | 42.9 | [42.9] | ||
| Sensitivity | % | 81.5 | 81.0 | [100.0] | ||
| PPV | % | 86.9 | 86.4 | [20.0] | ||
| NPV | % | 50.0 | 50.0 | [100.0] | ||
| tTau > 1150 pg/ml | ||||||
| Specificity | % | 71.4 | 71.4 | [71.4] | ||
| Sensitivity | % | 95.4 | 95.2 | [100.0] | ||
| PPV | % | 93.0 | 93.8 | [33.3] | ||
| NPV | % | 76.9 | 76.9 | [100.0] | ||