Table 1.
This table summarizes correlation analyses between: (a) Myc and TERT expression, (b) Myc expression and telomerase activity in various types of cancers.
| Cancer type (number of studies) | Correlation between TERT and Myc mRNA expressiona | Correlation between telomerase activity and Myc mRNA expressionb | References |
|---|---|---|---|
| Breast Cancer (n = 4) | No correlation | Not reported | Kirkpatrick et al., 2003b, 2004; Elkak et al., 2005; Bodvarsdottir et al., 2007 |
| Cervical cancer (n = 1) | Positive | Not reported | Sagawa et al., 2001 |
| Hepatocellular carcinoma (n = 2) | No correlation | Not reported | Chen et al., 2002; Liu et al., 2004 |
| Ovarian cancer (n = 1) | No correlation | Positive | Wisman et al., 2003 |
| Non-small cell lung cancer (n = 1) | Positive | Not reported | Geng et al., 2003 |
| Lymphoma (n = 1) | Positive | Positive | Klapper et al., 2003 |
| Malignant lipomatous tumors (n = 1) | Positive | Positive | Schneider-Stock et al., 2003 |
| Colon cancer (n = 1) | Positive | Not reported | Georgakopoulos et al., 2013 |
| Gastric cancer (n = 1) | Positive | Not reported | Silva et al., 2012 |
| Prostate cancer (n = 1) | Positive | Not reported | Latil et al., 2000 |
Positive correlation: high Myc expression co-occurs with high TERT mRNA expression or telomerase activity. No correlation: Myc levels and TERT mRNA expression or Myc levels and telomerase activity show no significant association. Not reported: the investigating group did not examine the correlation.