Table 1.

Characteristics of published guidelines for thromboprophylaxis in children.

Reference	Target population	Risk categories	Criteria	Interventions
Braga and Young (10)	Children in the pediatric intensive care unit (PICU)	Low risk	Immobility	Early mobilization and adequate hydration
		At risk	≥1 additional risk factor for VTE	Mechanical prophylaxis, pharmacologic prophylaxis to be considered for children with burns
Raffini et al. (11)	Children ≥14 years old	Low risk	No risk factors for VTE	Early ambulation
		At risk	≥1 risk factor (excluding immobility) or immobility without other risk factors for VTE	Mechanical prophylaxis
		High risk	Immobility with ≥1 additional risk factor for VTE	Mechanical and (strong consideration) pharmacologic prophylaxis
Hanson et al. (12)	Children admitted to the PICU after trauma	Low risk of VTE	<13 years old and ≤3 risk factors for VTE	None
		High risk of VTE with high risk of bleeding	≥13 years old or <13 years old with ≥4 risk factors for VTE and ≥1 risk factor for bleeding	Mechanical prophylaxis and surveillance ultrasound
		High risk of VTE with low risk of bleeding	≥13 or <13 years old with ≥4 risk factors for VTE and no risk factor for bleeding	Mechanical and pharmacologic prophylaxis
Meier et al. (14)	Children 10–17 years old	Low risk	No risk factors for VTE	Early ambulation and mitigation of risk factors
		Moderate risk	≥1 risk factor for VTE (excluding immobility) or immobility with ≤1 risk factor for VTE	Mechanical prophylaxis
		High risk	Immobility with ≥2 risk factors	Mechanical and pharmacologic (to be considered) prophylaxis
Mahajerin et al. (13)	Children >12 years old	Low risk	No risk factors for VTE	Early ambulation
		Moderate risk	Combinations of risk factors for VTE determine moderate versus high risk	Mechanical prophylaxis
		High risk		Mechanical and pharmacologic prophylaxis

VTE, venous thromboembolism.