Figure 3.

Twenty-four weeks of high-fat diet increased vascular sympathetic tone in male mice. Changes in mean arterial pressure in response to mecamylamine [ganglionic blocker (5 mg/Kg i.p)] in control- (CD) and high fat-fed (HFD) male and female mice, measured by radio-telemetry in conscious animals. Data are expressed as percentage of basal condition. Data are presented as mean ± SEM. ^*P < 0.05 vs. control diet within sex group; ^†P < 0.05 vs. male/ female within diet group. (n per group: CD male: 5; CD female: 5; HFD male: 6; HFD female: 5)