Figure 5.

Twenty-four weeks of high-fat diet reduced vascular adrenergic tone in male mice only. Cumulative concentration-response curves to phenylephrine and serotonin (5-HT) performed in aortic rings taken from control- (CD) and high fat fed (HFD) male (A,C) and female (B,D) mice and (E) KCl-induced vascular contractility measured in aortic rings taken from control- (CD) and high fat-fed (HFD) male and female mice. Data are expressed as percentage of KCl-induced contractility. Data are presented as mean ± SEM. ^*P < 0.05 vs. control diet within sex group; ^†P < 0.05 vs. high-fat diet within sex group. (n per group: CD male: 5; CD female: 5; HFD male: 5; HFD female: 6).