Figure 3.

BLISS accurately describes in vitro and in vivo data. (A) The relative keratinocyte density is computed (solid black line) for irradiation schemes with fluences between 0 and 100 Jcm⁻² and compared to the experimental data (Liebmann et al., 2010) of keratinocytes irradiated with three fluences of continuous wave blue light (gray dot). (B) The changes in the severity of a psoriasis lesion during (blue bar) and after treatment (black bar) are predicted (solid lines) for a pulsed wave treatment at high (red) and low (blue) intensities. These changes in the severity of the disease are shown in terms of the local psoriasis severity index (LPSI). The in silico results are compared to the clinical data (dots) of Pfaff et al. (2015).