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. 2017 Jan 26;8:28. doi: 10.3389/fphys.2017.00028

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Copyright © 2017 Félix Garza, Liebmann, Born, Hilbers and van Riel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Multiple parameter sensitivity shows that variations in the proliferation parameters have a high impact on the final keratinocyte cell densities and the local severity of psoriasis at the end of treatment. (A) The sensitivity of healthy and diseased keratinocytes (x axis) to variations in the 58 model parameters (y axis) is depicted in the heat map. Only those with a Kolmogorov–Smirnov statistic value higher than 0.3 are shown in the y axis. (B) The sensitivity of the treatment outcome to changes in the same model parameters of Panel (A) are shown in the bar plot in terms of the local psoriasis severity index. Only those parameters with a Kolmogorov-Smirnov statistic value higher than 0.3 are shown in the x axis.