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. 2017 Jan 26;8:28. doi: 10.3389/fphys.2017.00028

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Copyright © 2017 Félix Garza, Liebmann, Born, Hilbers and van Riel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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High fluences of blue light yield higher management of psoriasis than low fluences. (A) The LPSI over time is computed for a 12 weeks continuous wave treatment with an initial LPSI of 5.17 (Pfaff et al., 2015) using 11 fluences. (B) The behavior of the blue light factor θ_BLγ and the proliferation rate are visualized as functions of the fluence. (C) The bi-stability of the model is evaluated in the logarithmic scale for a wide range of fluences in a phase diagram of healthy and diseased keratinocytes. Only fluences above 500 Jcm⁻² yield a shift the dominant keratinocyte population and the phenotype of the skin. (D) Fluences below this level remain in the disease state.