Table 2.
FUT2 gene polymorphisms in patients with inflammatory bowel disease (IBD) and the controls.
| FUT2 | Controls | UC | CD | UC versus Controls | CD versus Controls | ||
|---|---|---|---|---|---|---|---|
| n (%) | n (%) | n (%) | OR (95% CI) | P | OR (95% CI) | P | |
| C357T | |||||||
| TT | 379 | 292 | 217 | 1 | 1 | ||
| TC (additive model) | 112 | 91 | 57 | 1.055 (0.759–1.463) | 0.742 | 0.889 (0.608–1.291) | 0.521 |
| CC (additive model) | 11 | 13 | 1 | 1.534 (0.624–3.839) | 0.302 | 0.159 (0.004–0.996) | 0.045 |
| Dominant model (TC+CC versus TT) | 1.097 (0.811–1.485) | 0.547 | 0.824 (0.578–1.173) | 0.282 | |||
| Recessive model (CC versus TT+TC) | 1.515 (0.671–3.419) | 0.314 | 0.824 (0.578–1.173) | 0.282 | |||
| Allele frequency model (C allele versus T allele) | 1.125 (0.861–1.471) | 0.387 | 0.780 (0.563–1.080) | 0.134 | |||
| A385T | |||||||
| AA | 150 | 122 | 80 | 1 | 1 | ||
| AT (additive model) | 269 | 204 | 119 | 0.932 (0.691–1.259) | 0.648 | 0.829 (0.586–1.1773) | 0.290 |
| TT (additive model) | 83 | 70 | 76 | 1.037 (0.697–1.544) | 0.858 | 1.717 (1.136–2.594) | 0.010 |
| Dominant model (AT+TT versus AA) | 0.957 (0.719–1.274) | 0.764 | 1.039 (0.752–1.435) | 0.818 | |||
| Recessive model (TT versus AA+AT) | 1.084 (0.764–1.537) | 0.651 | 0.519 (0.364–0.739) | 0.000 | |||
| Allele frequency model (T allele versus A allele) | 1.004 (0.832–1.212) | 0.964 | 1.271 (1.031–1.565) | 0.024 | |||
| G428A | |||||||
| GG | 497 | 392 | 266 | 1 | 1 | ||
| GA (additive model) | 5 | 4 | 9 | 1.014 (0.271–3.802) | 0.983 | 3.363 (1.116–10.137) | 0.044 |
| AA (additive model) | 0 | 0 | 0 | NA | NA | ||
| Dominant model (GA+AA versus GG) | 1.014 (0.271–3.802) | 0.983 | 3.363 (1.116–10.137) | 0.044 | |||
| Recessive model (AA versus GG+GA) | NA | NA | |||||
| Allele frequency model (A allele versus G allele) | 1.014 (0.271–3.789) | 1.000 | 3.324 (1.108–9.968) | 0.023 | |||
P value, OR, and 95% CI were calculated by chi-squared test. Threshold of P value is 0.05. P values of statistical significance are in bold. NA, not calculated due to low frequencies. CI, confidence interval; OR, odds ratio. The first row of each comparison group was set as reference.