Table 1.

Subjective evaluation of pigmentation and hydration before and after treatment. Pigmentation was more reduced on the treated hand than on the untreated, without reaching statistical significance. Hydration was significantly reduced in the treated hand after treatment compared to baseline (^∗∗p ≤ 0.01) and compared to untreated hand after 3 months of moisturization with a standard cream (⁺⁺p ≤ 0.01).

	Treated hand	Nontreated hand
Pigmentation before	1.1 ± 0.7	1.3 ± 0.7
Pigmentation after	0.9 ± 0.0	1.2 ± 0.6
Hydration before	2.0 ± 0.7	1.9 ± 0.7
Hydration after	3.0 ± 0.0∗∗	1.7 ± 0.7++