Table 5.
Effect of PEE on ALT, AST, ALP, and TP in ethanol-induced liver damage in rats.
| Study groups |
Treatment administered |
ALT | AST | ALP | TP |
|---|---|---|---|---|---|
| Normal control | Saline (1 mL/kg/day) | 49.49 ± 4.647 | 155.4 ± 6.197 | 270.71 ± 48.66 | 5.2 ± 0.31 |
| Disease control | 70% ethanol (10 mL/kg/day) | 103.9 ± 16.33### | 301.8 ± 17.91### | 396.4 ± 17.07# | 3.017 ± 0.31### |
| SIL25 | Silymarin (25 mg/kg/day) | 56.20 ± 1.953∗∗ | 230.5 ± 21.65∗ | 278.6 ± 4.351∗ | 4.9 ± 0.50∗∗ |
| PEE500 | PEE (500 mg/kg/day) | 61.20 ± 4.693∗∗ | 189.8 ± 8.84∗∗∗ | 267.1 ± 14.15∗ | 5.283 ± 0.25∗∗∗ |
| PEE1000 | PEE (1000 mg/kg/day) | 69.03 ± 3.66∗ | 210.8 ± 17.82∗∗ | 360.9 ± 44.92 | 5.133 ± 0.35∗∗ |
ALT: alanine aminotransferase, AST: aspartate aminotransferase, ALP: alkaline phosphatase, and TP: total protein. All values are expressed as mean ± SEM of at least 6 animals from each experimental group. Data found significant when One Way ANOVA followed by Dunnett's multiple comparison test performed. p < 0.05 was considered to be significant. Statistical significance (#p < 0.05; ##p < 0.01; ###p < 0.001) compared with the normal control group and (∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001) compared with the disease control group.