Table 6.
Effect of PEE on histopathological activity index in ethanol-induced liver damage in rats.
| Study groups |
Sinusoidal congestion in hepatic parenchyma |
Degenerative changes of hepatocytes, cellular swelling, vacuolar changes with granular cytoplasm of hepatocytes |
Necrotic changes of hepatic parenchyma, loss of nucleus, fragmentation of nuclei, centrilobular, midzonal necrosis |
Bile duct hyperplasia |
Perivascular lymphoid aggregation |
Infiltration of mononuclear cells (MNC), formation of microgranuloma |
Fatty liver (lipid deposition in hepatocyte), steatosis |
Overall pathological grade (lesion score) |
|---|---|---|---|---|---|---|---|---|
| Normal control | +/focal | NAD | NAD | NAD | +/focal | NAD | +/focal | NAD |
| Disease control | ++ | + ++ | ++ | + | + | NAD | ++ | +++ |
| SIL25 | NAD | +/focal | NAD | NAD | NAD | NAD | NAD | + |
| PEE500 | NAD | +/focal | +/focal | + | NAD | +/focal | NAD | ++ |
| PEE1000 | NAD | + | + | +/focal | NAD | NAD | NAD | + |
n = 4 per experimental group. No abnormality detected (NAD), minimal pathological changes (+), mild pathological changes (++), moderate pathological changes (+++), and severe pathological changes (++++). Focal and minimal changes may not be significant for alteration of functional capacity of the organ.