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SFRP1 methylation (A) at each of the 7 CpG sites quantified within the SFRP1 promoter region in DNA from rectal mucosal biopsies for participants at baseline (n = 69). Error bars represent SEMs. (B) Inverse relation between the mean methylation of 7 CpG sites within the SFRP1 promoter and SFRP1 mRNA expression in the human rectal mucosa at baseline (Spearman rank correlation analysis) (n = 36; R2 = 0.073; P = 0.240). SFRP1, secreted frizzled-related protein 1.
