Table 4.

The top 36 most statistically significant CpG sites that did not return to never-smoker levels 30 years after smoking cessation in the Framingham Heart Study (N=2,648)

Probe ID	Chr	Location	Gene Symbol	P
cg05951221	2	233284402		3.2 × 10−15
cg06644428	2	233284112		1.2 × 10−14
cg05575921	5	373378	AHRR	6.5 × 10−14
cg21566642	2	233284661		8.6 × 10−10
cg03636183	19	17000585	F2RL3	5.7 × 10−7
cg06126421	6	30720080		1.3 × 10−6
cg01940273	2	233284934		1.9 × 10−6
cg23771366	11	86510998	PRSS23	3.1 × 10−6
cg17272563	6	32116548	PRRT1	4.4 × 10−6
cg23916896	5	368804	AHRR	1.3 × 10−5
cg11660018	11	86510915	PRSS23	1.3 × 10−5
cg08118908	16	15787920	NDE1	3.0 × 10−5
cg13937905	12	53612551	RARG	1.5 × 10−4
cg24172324	2	232258363		1.7 × 10−4
cg10780313	6	33501379		2.0 × 10−4
cg14027333	6	32116317	PRRT1	2.1 × 10−4
cg11245297	19	8117898	CCL25	2.1 × 10−4
cg01692968	9	108005349		3.1 × 10−4
cg00706683	2	233251030	ECEL1P2	3.4 × 10−4
cg25317941	2	233351153	ECEL1	4.0 × 10−4
cg25189904	1	68299493	GNG12	4.0 × 10−4
cg14179389	1	92947961	GFI1	4.7 × 10−4
cg13641317	3	127255552		4.9 × 10−4
cg19847577	15	29213748	APBA2	5.1 × 10−4
cg14239618	7	110281356		5.8 × 10−4
cg25955180	6	32116538	PRRT1	6.3 × 10−4
cg00774149	3	52255721	TLR9	6.4 × 10−4
cg21351392	6	161607487	AGPAT4	7.1 × 10−4
cg11902777	5	368843	AHRR	7.6 × 10−4
cg07251887	17	73641809	LOC100130933; RECQL5	7.7 × 10−4
cg19382157	7	2124566	MAD1L1	8.9 × 10−4
cg19925780	1	101509557		1.1 × 10−3
cg03679544	6	155537972	TIAM2	1.1 × 10−3
cg08559712	20	16030674	MACROD2	1.3 × 10−3
cg09837977	7	110731201	LRRN3; IMMP2L	1.3 × 10−3
cg00931843	6	155442993	TIAM2	1.4 × 10−3

^*CpG sites without gene names are intergenic. These are all included in all the analyses.