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. 2017 Jan 17;18(Suppl 1):3. doi: 10.1186/s12860-016-0118-4

Table 4.

Residues and domains implicated in the stability and the docking of hemichannels for cardiac Cx40, Cx43 and Cx45 expressed in myocytes

Stability and docking of hemichannels
Domains Motifs
Cx40 NTH
E1
E2		 Similar to the motifs ensuring the stability of connexins
ExxxE [62–64]
DxQI
53-CxxxxxxCxxC-66 (mCx40)
VxxxxxxxHPxN
184-CxxxxxxCxxxC-197 (mCx40)
Cx43 NTH
E1
E2		 Similar motifs to the motifs ensuring the stability of connexins
KxxxK [62–64]
NxLQ
53-CxxxxxxCxxC-65 (mCx43)
TxxxxxxxHQxD
186-CxxxxxxCxxxC-199 (mCx43)
Cx45 NTH
E1
E2		 Similar motifs to the motifs ensuring the stability of connexins
RxxxE [65]
NxLQ
52-CxxxxxxCxxC-63 (mCx45)
VxxxxxxxHKxD
208-CxxxxxxCxxxC-221 (mCx45)

In bold and underlined are specific residues implicated in the fine regulation of the formation of GJCs (see text for more details). n.d.: not determined