. Author manuscript; available in PMC: 2017 Oct 18.

Published in final edited form as: J Scleroderma Relat Disord. 2016 Oct 18;1(3):247–256. doi: 10.5301/jsrd.5000214

Table I.

Medications for the treatment of gastrointestinal manifestations in systemic sclerosis

Manifestation	Medication class	Medication example	Dosing information
GERD	proton-pump inhibitor	omeprazole	20-40 mg 1-2 times daily 30-60 min before a meal
	histamine type-2 receptor antagonist	ranitidine	150 mg 1-2 times or 300 mg once daily
	GABA-B agonist	baclofen	5-10 mg up to 3 times daily
Gastroparesis	dopamine receptor antagonist	metoclopramide	10 mg up to 4 times daily
	dopamine receptor antagonist	domperidone	10 mg up to 4 times daily
	motilin receptor agonist	erythromycin	250-500 mg 3 times daily up to 4 weeks
Small intestinal pseudo- obstruction	somatostatin analogue	octreotide	50-100 mcg SC nightly or 3 times daily
Small intestinal bacterial overgrowth	antibiotics	rifaximin	550 mg 2 times daily for 10-14 days
Small intestinal bacterial overgrowth	antibiotics	metronidazole	500 mg 2 times daily for 10-14 days
Constipation	stool softener (hyperosmolar)	polyethylene glycol	17 gm daily, then titrated to effect
	stimulant laxative	bisacodyl	5-15 mg daily
	secretagogue	linaclotide	145 mcg daily
Colonic pseudo- obstruction	cholinesterase inhibitor	neostigmine	2 mg IV over 3-5 minutes