Table 2.
Histopathological alterations in constipated SD rats after Urd treatment
| Contents | No | Urd | Lop | |
|---|---|---|---|---|
| Vehicle | Urd | |||
| Mucosa layer thickness (μm) | 394 ± 35.2 | 415 ± 21.3 | 105 ± 12.5* | 402 ± 23.5# |
| Muscle thickness (μm) | 89.3 ± 6.5 | 92.3 ± 7.6 | 28.3 ± 4.3* | 90.2 ± 6.6# |
| Flat luminal surface thickness (μm) | 16.1 ± 3.2 | 15.4 ± 2.3 | 10.6 ± 1.1* | 14.8 ± 2.0# |
| Number of goblet cells (ea) | 85.6 ± 8.5 | 88.4 ± 6.7 | 51.2 ± 5.5* | 72.6 ± 9.8# |
| Number of crypt of lieberkuhn (ea) | 12.5 ± 2.6 | 14.2 ± 1.5 | 5.8 ± 1.1* | 11.2 ± 2.1# |
| Number of enterocytes (ea) | 125.2 ± 8.6 | 117.8 ± 7.7 | 82.3 ± 9.2* | 102.4 ± 7.8# |
*p < 0.05 compared with the non-constipation group. # p < 0.05 compared with the Lop + Vehicle treated constipation group. Urd; uridine, Lop; loperamide