Table 2.
Quantitative comparison of overlap human milk serum and bovine milk serum (Bold proteins are significantly different proteins by one-way ANOVA; the values are log10 average iBAQ values of proteins; Human milk samples were collected from 10 healthy mothers that were between 3 and 10 months in lactation; Bovine milk samples were collected from 30 clinically healthy cows that were between 3 weeks and 10 months in lactation; data was normally distributed)
| Gene name | Protein name | HS | CS | Log2 (HS/CS) | P value |
|---|---|---|---|---|---|
| ALB | Serum albumin | 7.30 | 5.27 | 6.75 | 0.000 |
| FASN | Fatty acid synthase | 4.38 | 2.40 | 6.59 | 0.000 |
| XDH | Xanthine dehydrogenase | 5.36 | 3.59 | 5.86 | 0.000 |
| SERPINA3 | Alpha-1-antichymotrypsin | 5.44 | 4.02 | 4.72 | 0.000 |
| LTF | Lactoferrin | 7.17 | 5.84 | 4.44 | 0.002 |
| PRSS1 | Alpha-trypsin chain 1 | 6.74 | 5.42 | 4.39 | 0.000 |
| CD14 | Monocyte differentiation antigen CD14 | 5.52 | 4.24 | 4.23 | 0.000 |
| CLU | Clusterin | 5.74 | 4.64 | 3.66 | 0.002 |
| CSN2 | Beta-casein | 7.80 | 6.79 | 3.34 | 0.002 |
| LDHB | L-lactate dehydrogenase B chain | 4.25 | 3.30 | 3.16 | 0.124 |
| SERPINA1 | Alpha-1-antitrypsin | 5.38 | 4.62 | 2.52 | 0.007 |
| PIGR | Polymeric immunoglobulin receptor | 6.47 | 5.84 | 2.08 | 0.003 |
| GC | Vitamin D-binding protein | 5.20 | 4.64 | 1.89 | 0.026 |
| LPL | Lipoprotein lipase | 4.05 | 3.56 | 1.65 | 0.043 |
| SPP1 | osteopontin | 6.35 | 5.95 | 1.34 | 0.107 |
| HSPA8 | Heat shock 70 kDa protein 8 | 3.89 | 3.51 | 1.25 | 0.277 |
| LALBA | Alpha-lactalbumin | 7.79 | 7.49 | 1.00 | 0.073 |
| SERPINF2 | Alpha-2-plasmin inhibitor | 3.89 | 3.60 | 0.95 | 0.302 |
| FABP3 | Fatty acid-binding protein 3 | 5.33 | 5.13 | 0.66 | 0.359 |
| B2M | Beta-2-microglobulin | 5.47 | 5.36 | 0.37 | 0.779 |
| BTN1A1 | Butyrophilin subfamily 1 member A1 | 5.60 | 5.53 | 0.23 | 0.679 |
| NUCB2 | Nucleobindin 2 | 4.44 | 4.40 | 0.12 | 0.543 |
| PLIN2 | Perilipin-2 | 4.49 | 4.46 | 0.10 | 0.943 |
| CSN1S1 | Alpha-S1-casein | 7.33 | 7.31 | 0.10 | 0.836 |
| APOE | Apolipoprotein E | 3.81 | 3.99 | −0.59 | 0.285 |
| SERPINC1 | Antithrombin-III | 3.86 | 4.05 | −0.64 | 0.677 |
| RAB18 | Ras-related protein Rab-18 | 3.70 | 3.96 | −0.86 | 0.725 |
| MFGE8 | Lactadherin | 4.88 | 5.16 | −0.94 | 0.402 |
| NPC2 | Epididymal secretory protein E1 | 4.49 | 4.89 | −1.32 | 0.513 |
| C3 | Complement C3 | 4.56 | 4.96 | −1.33 | 0.074 |
| AZGP1 | Zinc-alpha-2-glycoprotein | 4.88 | 5.32 | −1.47 | 0.197 |
| AHSG | Alpha-2-HS-glycoprotein | 4.32 | 4.83 | −1.69 | 0.149 |
| IGL@ | IGL@ protein | 6.19 | 6.76 | −1.88 | 0.025 |
| CFB | Complement factor B | 2.66 | 3.27 | −2.03 | 0.138 |
| ORM1 | Alpha-1-acid glycoprotein 1 | 4.94 | 5.56 | −2.04 | 0.298 |
| FGFBP1 | Fibroblast growth factor-binding protein 1 | 3.69 | 4.64 | −3.16 | 0.002 |
| LPO | Leucine-rich alpha-2-glycoprotein | 4.25 | 5.23 | −3.26 | 0.004 |
| NUCB1 | Nucleobindin 1 | 4.05 | 5.35 | −4.30 | 0.008 |
| IDH1 | Isocitrate dehydrogenase 1 | 3.00 | 4.48 | −4.92 | 0.007 |