Fig. 3.

Non-canonical control of GLI activity by oncogenic mechanisms involving kinases, and epigenetic modulators. Rationale-based small-molecule targeting of these GLI regulatory signals with clinically approved/suitable drugs alone or in combination with HH pathway inhibitors such as direct GLI antagonists may generate efficient therapeutic effects. HPI-1: Hedgehog Pathway Inhibitor-1 acting at the level of GLI proteins [68], GANT61: direct GLI antagonist 61 [50], Glab B: glabrescione B (direct GLI inhibitor interfering with DNA binding) [67], HDACi: HDAC inhibitors