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. 2017 Jan 25;18:17. doi: 10.1186/s13059-016-1143-5

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Differential methylation analysis results, with normal control. a Numbers of differential methylated CpG sites (FDR < 0.01). b Spatial correlations among test statistics from nearby CpG sites. c Average pan-cancer correlation of test statistics. d Enrichment p values for top 1000 differentially methylated genes within “PATHWAY-IN-CANCER” from KEGG