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. 2017 Jan 25;18:17. doi: 10.1186/s13059-016-1143-5

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Differential methylation analysis, without normal control. a Examples of ROC curves from InfiniumPurify control-free DMC calling model, where results from tumor-normal comparison are treated as gold standard. b AUCs for selected cancer types in TCGA. c Heatmap showing overlaps of the top 50,000 DMCs among different cancer types