Fig. 2.
Experiment 1. The dose accumulative effects of carbachol (A), angiotensin II (B), and PGE2 (C) on intact colonic sections ex vivo after 16-week treatment with enalapril (triangles) or hydralazine (squares) from 25-week-old SHRs compared with no-treatment SHR controls (circles). The data are expressed as the mean ± S.E.M. from six to eight rats. Using analysis of variance, there were no significant differences in maximal contractions or sensitivities across the groups. The calculated maximal contraction (mm/g), sensitivity (EC50), and area under the curve for each electrical stimulation and the gastrointestinally active agents in the colon are shown in Table 2.