Fig. 3.
Experiment 2. The dose accumulative effects of carbachol (A), angiotensin II (B), and PGE2 (C) on intact ileal sections ex vivo after 16-week treatment with losartan (filled circles) from 25-week-old SHRs compared with no-treatment SHR controls (open circles). The data are expressed as the mean ± S.E.M. from six to eight rats. Using Student’s t tests, there were significant differences at the doses shown for carbachol and angiotensin II and between the groups (P < 0.05). The calculated maximal contraction (mm/g), sensitivity (EC50), and area under the curve for the gastrointestinally active agents in the ileum are shown in Table 3.