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. 2017 Feb;360(2):260–266. doi: 10.1124/jpet.116.237586

TABLE 1.

Experiment 1, effects of antihypertensive agents enalapril and hydralazine in drinking water for 16 weeks on the contractility of SHR isolated intact sections of ileum ex vivo by KCl and agonists carbachol, angiotensin II, and PGE2 compared with no-treatment SHR control

Results are the mean ± S.E.M. from six to eight rats. Statistics were performed using one-way analysis of variance. There were no significant differences between the groups (results not shown).

Control Enalapril Hydralazine
KCl (40 mM)
 Max (mm/g) 71.2 ± 15.8 74.3 ± 12.4 63.0 ± 9.5
Carbachol
 EC50 (nM) 137 ± 26 300 ± 70 255 ± 24
 Max (mm/g) 92.4 ± 8.7 98.9 ± 13.2 83.1 ± 9.6
 AUC 141 ± 18 169 ± 23 137 ± 20
Angiotensin II
 EC50 (nM) 12.0 ± 1.5 17.2 ± 3.7 23.2 ± 5.8
 Max (mm/g) 52.9 ± 6.6 46.3 ± 7.6 51.0 ± 7.4
 AUC 82.1 ± 9.9 72.2 ± 14.9 74.3 ± 13.6
PGE2
 EC50 (nM) 1624 ± 249 3813 ± 1002 2169 ± 562
 Max (mm/g) 39.0 ± 8.2 40.0 ± 6.6 47.5 ± 6.7
 AUC 29.0 ± 5.4 35.2 ± 12.1 43.7 ± 9.0

AUC, area under the curve as arbitrary units; Max, maximal derived contraction of the tissue.

HHS Vulnerability Disclosure