TABLE 1.
Experiment 1, effects of antihypertensive agents enalapril and hydralazine in drinking water for 16 weeks on the contractility of SHR isolated intact sections of ileum ex vivo by KCl and agonists carbachol, angiotensin II, and PGE2 compared with no-treatment SHR control
Results are the mean ± S.E.M. from six to eight rats. Statistics were performed using one-way analysis of variance. There were no significant differences between the groups (results not shown).
Control | Enalapril | Hydralazine | |
---|---|---|---|
KCl (40 mM) | |||
Max (mm/g) | 71.2 ± 15.8 | 74.3 ± 12.4 | 63.0 ± 9.5 |
Carbachol | |||
EC50 (nM) | 137 ± 26 | 300 ± 70 | 255 ± 24 |
Max (mm/g) | 92.4 ± 8.7 | 98.9 ± 13.2 | 83.1 ± 9.6 |
AUC | 141 ± 18 | 169 ± 23 | 137 ± 20 |
Angiotensin II | |||
EC50 (nM) | 12.0 ± 1.5 | 17.2 ± 3.7 | 23.2 ± 5.8 |
Max (mm/g) | 52.9 ± 6.6 | 46.3 ± 7.6 | 51.0 ± 7.4 |
AUC | 82.1 ± 9.9 | 72.2 ± 14.9 | 74.3 ± 13.6 |
PGE2 | |||
EC50 (nM) | 1624 ± 249 | 3813 ± 1002 | 2169 ± 562 |
Max (mm/g) | 39.0 ± 8.2 | 40.0 ± 6.6 | 47.5 ± 6.7 |
AUC | 29.0 ± 5.4 | 35.2 ± 12.1 | 43.7 ± 9.0 |
AUC, area under the curve as arbitrary units; Max, maximal derived contraction of the tissue.