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. 2017 Feb;360(2):260–266. doi: 10.1124/jpet.116.237586

TABLE 2.

Experiment 1, effects of antihypertensive agents enalapril and hydralazine in the drinking water for 16 weeks on the contractility of SHR isolated intact sections of proximal colon ex vivo by KCl; electrical stimulation; and agonists carbachol, angiotensin II, and PGE2 compared with no-treatment SHR control

Results are mean ± S.E.M. from six to eight rats. Statistics were performed using one-way analysis of variance. There were no significant differences between the groups (results not shown).


Control
Enalapril
Hydralazine
KCl (40 mM)
 Max (mm/g) 21.2 ± 3.7 19.7 ± 3.6 20.1 ± 4.5
Electrical stimulation
 Max (mm/g) 17.1 ± 1.7 14.5 ± 3.4 13.5 ± 2.4
Carbachol
 EC50 (nM) 159 ± 27 186 ± 57 207 ± 77
 Max (mm/g) 40.7 ± 6.6 32.9 ± 5.2 41.7 ± 4.4
 AUC 79.7 ± 12.8 63.5 ± 7.5 79.6 ± 11.4
Angiotensin II
 EC50 (nM) 2.7 ± 0.5 2.7 ± 0.7 3.3 ± 0.7
 Max (mm/g) 32.7 ± 3.4 30.6 ± 4.1 32.4 ± 3.0
 AUC 72.7 ± 8.7 68.2 ± 8.8 68.9 ± 7.0
PGE2
 EC50 (nM) 67.3 ± 20.9 52.7 ± 17.8 208 ± 67
 Max (mm/g) 32.2 ± 1.1 32.3 ± 2.4 32.2 ± 2.8
 AUC 74.7 ± 6.5 79.1 ± 7.5 79.6 ± 11.4

AUC, area under the curve as arbitrary units; Max, maximal derived contraction of the tissue.

HHS Vulnerability Disclosure