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. 2017 Feb;360(2):260–266. doi: 10.1124/jpet.116.237586

TABLE 3.

Experiment 2, effects of losartan in drinking water for 16 weeks on SHR contractility of intact ileum and proximal colon sections ex vivo by KCl, agonists (carbachol, angiotensin II, and PGE2), and electrically driven colon and tissue densities compared with no-treatment SHR control

Results are mean ± S.E.M. from six to eight rats. Statistics were performed using Student’s t test.


Control
Losartan
P Value
Ileum
 KCl (10 mM) Max (mm/g) 22.6 ± 7.8 61.1 ± 10.1 0.013
 KCl (40 mM) Max (mm/g) 49.3 ± 11.0 108.3 ± 12.2 0.005
 Carbachol
  EC50 (nM) 798 ± 343 253 ± 23 ns
  Max (mm/g) 79 ± 17 130 ± 15 0.048
  AUC 117 ± 33 226 ± 29 0.033
 Angiotensin II
  EC50 (nM) 4.7 ± 2.1 43.1 ± 13.2 0.017
  Max (mm/g) 82.5 ± 18.1 44.6 ± 11.9 ns
  AUC 194.7 ± 55.6 49.0 ± 10.5 0.028
 PGE2
  EC50 (nM) 2383 ± 1081 1463 ± 266 ns
  Max (mm/g) 48.4 ± 12.3 69.1 ± 11.5 ns
  AUC 60.1 ± 24.9 68.6 ± 11.5 ns
Colon
 Electrical stimulation 15.7 ± 5.3 14.0 ± 3.0 ns
 KCl (10 mM) Max (mm/g) 8.16 ± 3.04 4.11 ± 1.16 ns
 KCl (40 mM) Max (mm/g) 60.7 ± 9.1 57.7 ± 8.1 ns
 Carbachol
  EC50 (nM) 209 ± 24 170 ± 8 ns
  Max (mm/g) 74.4 ± 9.0 74.1 ± 9.0 ns
  AUC 135 ± 16 140 ± 18 ns
 Angiotensin II
  EC50 (nM) 4.66 ± 0.66 241.0 ± 91.1 0.027
  Max (mm/g) 27.1 ± 6.7 9.3 ± 2.2 0.030
  AUC 54.3 ± 14.4 4.5 ± 0.9 0.006
 PGE2
  EC50 (nM) 2078 ± 941 934 ± 231 ns
  Max (mm/g) 24.9 ± 5.5 16.1 ± 2.0 ns

AUC, area under the curve (as arbitrary units); Max, maximal derived contraction of the tissue; ns, not significant.

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