Fig. 1.

(A) Effects of CP55940 (upper) and spiradoline (lower) alone on tail withdrawal latency from 50°C water (squares), responding for food (diamonds), and body temperature (circles) in eight rats. Abscissae: cumulative dose in mg/kg body weight. Ordinate: percentage of maximum possible effect ±1 S.E.M. (B) Dot plot showing individual ED₅₀ values for CP55940 and spiradoline alone for the data presented in (A), except that open symbols are used to avoid concealing the mean (horizontal lines) and error (±1 S.E.M.). Abscissae: assays (rate of responding for food, body temperature, and antinociception) for both drugs. Ordinate: ED₅₀ values in mg/kg body weight.