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. 2017 Feb;91(2):110–122. doi: 10.1124/mol.116.106617

Fig. 8.

Fig. 8.

TCA treatment activated the intestinal FXR pathway and reduced Cd36 expression. After TCA treatment of 7 days, livers and intestines of male WT C57BL/6J mice were collected. Protein levels and gene expressions at mRNA level were measured. (A) Relative mRNA levels of Fxr, Shp, and Cyp7a1 gene in the liver. (B) Relative mRNA levels of Fxr, Fgf15, Ibabp, and OSTβ gene in the distal ileum. (C) Relative mRNA levels of Srebp-1c, Pparα, Acc, Fas and Cyp4a10 gene in the liver. (D) Relative mRNA levels of Mtp, ApoB, and Cd36 gene in the liver. (E) Semiquantitative analysis of the protein levels in the liver. (F) Protein level of CD36, p-ERK1/2 and T-ERK1/2 in the liver. Error bars show S.D. of replicates (n = 6). *P < 0.05; **P < 0.01, ***P < 0.001, compared with control group.