Table 1.
Baseline anthropometric measurements and resting hemodynamics
| PAD (N = 12) |
Healthy (N = 15) |
P-values | |
|---|---|---|---|
| Male / female | 7 / 5 | 9 / 6 | |
| Age, yr | 65 ± 2 | 64 ± 2 | 0.940 |
| Height, m | 1.67 ± 0.03 | 1.72 ± 0.02 | 0.104 |
| Weight, kg | 78.7 ± 3.6 | 75.2 ± 3.3 | 0.481 |
| Body Mass Index, kg/m2 | 28.1 ± 1.2 | 25.2 ± 0.7 | 0.072 |
| ABI exercising leg | 0.58 ± .03* | 1.09 ± .03 | < 0.001 |
| ABI non-exercising leg | 0.72 ± .06* | 1.07 ± .03 | < 0.001 |
| Pack years | 29 ± 8* | 0 ± 0 | < 0.001 |
| Systolic BP, mmHg | 143 ± 7* | 123 ± 3 | 0.014 |
| Diastolic BP, mmHg | 74 ± 2 | 76 ± 2 | 0.351 |
| Mean BP, mmHg | 96 ± 3 | 90 ± 2 | 0.194 |
| Heart Rate, beats/min | 63 ± 3* | 55 ± 2 | 0.020 |
| S’ cm/s | 9.1 ± 0.7 | 8.5 ± 0.5 | 0.497 |
| e’, cm/s | 8.7 ± 0.6 | 9.8 ± 0.6 | 0.209 |
| a’, cm/s | 10.2 ± 0.8 | 10.0 ± 0.7 | 0.877 |
| E, cm/s | 86.1 ± 4.3* | 72.7 ± 3.3 | 0.024 |
| A, cm/s | 90.4 ± 7.7* | 68.8 ± 1.6 | 0.021 |
| E-to-A ratio | 1.00 ± 0.05 | 1.06 ± 0.05 | 0.383 |
| E to e’ | 10.7 ± 0.9* | 7.6 ± 0.4 | 0.012 |
Values are mean ± SEM. ABI, ankle-brachial index; BP, blood pressure; S’, systolic mitral annulus velocity; e’, early diastolic mitral annulus velocity; a’, late diastolic mitral annulus velocity; E, early diastolic mitral inflow; A, late diastolic mitral inflow.
*
P < 0.05 compared to healthy control subjects