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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Sleep Med. 2015 Dec 31;20:18–24. doi: 10.1016/j.sleep.2015.12.010

Table 2.

Between group changes in sleep continuity variables compared to placebo.

Estimate SE Lower 95% CI Upper 95% CI p-value Effect Size
Sleep latency
CBT-I + Placebo vs. Placebo -18.62 5.25 -29.14 -8.10 <0.001** -0.67
CBT-I + Armodafinil vs. Placebo -16.16 5.27 -26.73 -5.59 0.003** -0.58
Armodafinil vs. Placebo 7.98 5.68 -3.45 19.41 0.17 0.29
CBT-I + Armodafinil vs. CBT-I + Placebo 2.46 4.67 -6.70 11.61 0.60 0.09

Wake after sleep onset
CBT-I + Placebo vs. Placebo -10.00 5.50 -20.96 0.96 0.07 -0.48
CBT-I + Armodafinil vs. Placebo -13.14 5.59 -24.27 -2.01 0.02 -0.64
Armodafinil vs. Placebo 10.23 7.56 -5.05 25.51 0.18 0.50
CBT-I + Armodafinil vs. CBT-I + Placebo -3.14 5.16 -13.24 6.97 0.54 -0.15

Total sleep time
CBT-I + Placebo vs. Placebo -28.69 19.43 -67.65 10.27 0.15 -0.39
CBT-I + Armodafinil vs. Placebo -16.00 20.36 -56.93 24.93 0.44 -0.22
Armodafinil vs. Placebo -51.30 21.80 -95.24 -7.37 0.02 -0.69
CBT-I + Armodafinil vs. CBT-I + Placebo 12.69 17.68 -21.97 47.35 0.47 0.17
*

P < 0.01,

**

P < 0.001 A significance level of 0.0125 was used to adjust for multiple comparisons. (Asterisks denote improvements compared to placebo for between group analyses.); All analyses used multiple imputation; P-values for between group analyses are from ANCOVA controlling for values at time of consent; Effect size is Cohen’s D.