Table 1.

Details of the 4 RCTs with patient level data included in this study.

Studies	Country/years	Intervention	Patients in study	Timing of CMR	Area-at-risk	Acute MI size	Outcome
Ludman [27]	UK/2007–2009	Erythropoietin	51	1–6 days	Endocardial surface area	10 min after 0.2 mmol/kg Dotarem,	Erythropoietin failed to reduce MI size
Crimi [28]	Italy/2009–2011	Remote ischemic conditioning of the lower limbs	100	3–5 days	T2-weighted imaging	15 min after 0.2 mmol/kg Magnevist	Reduction in enzymatic MI size in the intervention arm. Under-powered to see a difference in MI size by CMR
Garcia-Dorado [30]	Spain/2008–2011	Adenosine	201	2–7 days	T2-weighted imaging	10 min after 0.2 mmol/kg of Magnevist	No difference in acute MI size in the whole cohort
White [29]	UK/2011–2012	Remote ischemic conditioning of the upper limb	197	3–6 days	T2 mapping	10 min after 0.1 mmol/kg of Dotarem	27% reduction in MI size by CMR in the intervention arm

MI: myocardial infarct; CMR: cardiovascular magnetic resonance.