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. Author manuscript; available in PMC: 2018 Jan 3.
Published in final edited form as: Structure. 2017 Jan 3;25(1):157–166. doi: 10.1016/j.str.2016.11.019

Figure 6.

Figure 6

Model of DNA binding in the T7 Replisome

Docking model of the T7 replisome complex bound to a replication fork DNA. The leading and lagging strands are colored slate blue and orange, respectively. As single-stranded DNA passes through the central channel of the helicase, the displaced leading strand is diverted to Pol A for leading strand synthesis. The modeled lagging strand DNA is redirected by a replication loop to interact with Pol B. In this way, the crystal structure of the T7 replisome is suggestive of a simple mechanism for coupled replication of two antiparallel DNA strands.