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. Author manuscript; available in PMC: 2017 Jan 26.
Published in final edited form as: Cell Rep. 2017 Jan 24;18(4):947–960. doi: 10.1016/j.celrep.2016.12.075

Table 2.

NCI CTCAE grading system for hematologic toxicity

lineage Grade 1 Grade 2 Grade 3 Grade 4
Neutrophils <LLN to 1,500/mm3 1,000 to 1,500/mm3 500 to 1,000/mm3 <500/ mm3
Platelets <LLN to 75,000/mm3 50,000 to 75,000/mm3 25,000 to 50,000/mm3 <25,000/ mm3
Hemoglobin <LLN to 10 g/dL 8.0 to 10.0 g/dL <8.0 g/dL Life-threatening consequences
Lymphocytes (total) <LLN to 800/mm3 500 to 800/mm3 200 to 500/mm3 <200/ mm3

Neutropenia, thrombocytopenia, anemia, and lymphopenia were determined from the complete blood count after chemotherapy and the lowest count was used for calculating grade of toxicity. All patients with sustained fever of > 100.4°F in the midst of chemotherapy-induced grade 4 neutropenia received a first course of IV antibiotics in-hospital. Taken from NCI CTCAE, version 3.0: National Cancer Institute Common Terminology Criteria for Adverse Events; LLN: lower limit of normal.