Table 2.
Number of metastatic lesions in the isolated brain of test NuNu mice after administration of saline, hMTf, BTA and BT2111 biweekly for two weeks.
| Group | Dose, IP, biweekly for 2 weeks (mg/kg) |
Number of mice/group |
Number of metastatic lesions per animal (20 slides per animal) | |
|---|---|---|---|---|
| Mean ± STDEV | Range | |||
| Saline (control) |
NA | 9 | 85.0±18.9 | 69 – 131 |
| BT2111 | 17 | 8 | 27.6±11.1a | 16 – 47 |
| BTA | 10 | 13 | 74.2±18.0 | 39 – 99 |
| hMTf | 7 | 13 | 75.1±24.6 | 37 – 122 |
a
The P Value for BT2111 vs. control, BTA or hMTf groups was found to be < 0.0001.