Table 1. Proportion of simulations with early termination.
| Scenario | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | |
| 4 Dose Levels | ||||||||||||||||
| CRM | 0.00 | 0.02 | 0.05 | 0.12 | 0.04 | 0.06 | 0.01 | 0.01 | 0.47 | 0.01 | 0.01 | 0.66 | 0.00 | 0.01 | 0.00 | 0.00 |
| mTPI | 0.05 | 0.10 | 0.16 | 0.29 | 0.08 | 0.22 | 0.05 | 0.06 | 0.67 | 0.08 | 0.08 | 0.80 | 0.02 | 0.04 | 0.06 | 0.03 |
| BOIN | 0.00 | 0.03 | 0.07 | 0.22 | 0.02 | 0.12 | 0.01 | 0.01 | 0.67 | 0.01 | 0.01 | 0.76 | 0.00 | 0.01 | 0.01 | 0.01 |
|
| ||||||||||||||||
| 6 Dose Levels | ||||||||||||||||
| CRM | 0.54 | 0.03 | 0.04 | 0.06 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.00 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 |
| mTPI | 0.73 | 0.12 | 0.14 | 0.24 | 0.03 | 0.05 | 0.09 | 0.05 | 0.08 | 0.06 | 0.04 | 0.07 | 0.03 | 0.00 | 0.01 | 0.01 |
| BOIN | 0.74 | 0.05 | 0.08 | 0.15 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 |
|
| ||||||||||||||||
| 8 Dose Levels | ||||||||||||||||
| CRM | 0.15 | 0.01 | 0.00 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 |
| mTPI | 0.38 | 0.07 | 0.05 | 0.14 | 0.04 | 0.02 | 0.04 | 0.04 | 0.06 | 0.03 | 0.05 | 0.11 | 0.00 | 0.02 | 0.00 | 0.00 |
| BOIN | 0.34 | 0.01 | 0.01 | 0.07 | 0.00 | 0.00 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 |