Figure 3. Comparison of each nitroxide for mitigation of the effect of total body irradiation in vivo. JP4-039, XJB-5-131, TK649.030 and JRS527.084 were encapsulated in F14 liposomes (sesame seed oil, soy phosphatidyl choline and Dulbecco’s PBS). C57BL/6NTac mice were irradiated to a dose of 9.5 Gy total body irradiation. Twenty-four hours later, the mice were injected i.v. with F14 only, JP4-039/F14, XJB-5-131/F14, TK649.030/F14, or JRS527.084/F14 and followed for the development of hematopoietic syndrome. All four small molecules led to increased survival compared to mice treated with 9.5 Gy alone (p<0.05) (see Table I).