Recommendations—Investigation of POTS

	Class	Level
A complete history and physical exam with orthostatic vital signs and 12-lead ECG should be performed on patients being assessed for POTS.	I
Complete blood count and thyroid function studies can be useful for selected patients being Assessed for POTS.	IIa	E
A 24-hour Holter monitor may be considered for selected patients being assessed for POTS, although its clinical efficacy is uncertain.	IIb	E
Detailed autonomic testing, transthoracic echocardiogram, tilt-table testing, and exercise stress testing may be considered for selected patients being assessed for POTS.	IIb	E