Skip to main content
. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Bioessays. 2016 Dec 2;39(2):10.1002/bies.201600156. doi: 10.1002/bies.201600156

Figure 3.

Figure 3

Activation of Aurora-A during the IS by proteins from the GA. A: Regulation of Aurora-A activity during G2 phase. (1) Interaction of GM130 with importin a promotes the release of TPX2 and the consequent Aurora-A autophosphorylation, promoting local MT polymerization. (2) Aurora-A phosphorylation by Src allows Aurora-A localization at the centrosome for proper centrosomal maturation. B: Possible model of Aurora-A regulation during the IS. (1) Translocation of vesicles containing Lck from the TGN to the membrane is directed by MAL. (2) Activation of Aurora-A by TPX2 release next to the IS area. (3) Local MT polymerization from the GA through Aurora-A activation mediated by GM130 and AKAP450. (4) Activation of Aurora-A at the centrosome through Src activation. GA, Golgi apparatus; Imp a, importin a; MT, microtubule; TCR, T cell receptor; TGN, trans-Golgi network.