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. 2017 Jan 12;2(1):125–138. doi: 10.1016/j.chempr.2016.12.003

Scheme 1.

Scheme 1

EDOT Glyoxylation and Functionalization

(A) Treatment of EDOT with oxalyl chloride and subsequent treatment with the desired nucleophile generates functional end-capped derivatives, which can then undergo bromination (route A). Alternatively, amide or ester coupling can be undertaken from a common intermediate 10 to give the desired monomers (route B).

(B) Functionalized brominated monomers synthesized.