Table 2. List of human proteins obtained in the BioXGEM blast which share structural homology with CHIKV E1 glycoprotein.
The output was limited to 100 proteins only and all the human proteins in these were shortlisted and the most probable proteins that might contribute to the inflammation and arthritic pathology were considered.
| Protein ID | Name of the protein |
|---|---|
| 3EI4:E | hsDDB1-hsDDB2 complex—DNA damage binding proteins |
| 2A73:A | Human Complement Component C3 |
| 1FNF:A | Fibronectin (cell adhesion protein) |
| 1IGY: D | Intact IgG monoclonal antibody |
| 3II7:A | Kelch like protein |
| 3GC3:A | Beta arrestin 1 (adaptor protein in trafficking, binds to clathrin) |
| 2E9W:A | Mast/stem cell growth factor receptor |
| 3CU7:A | Complement protein 5 (P.S: C3 & C5 adopt similar core structure) |
| 2JK4:A | Voltage dependent anion channel protein 1 (mitochondrial porin) |
| 2FAU:A | Vacuolar protein sorting 26 (has arrestin fold) |
| 1VYH:S | Platelet activating factor acetyl hydrolase IB alpha subunit |
| 1K8K:C | ARP 2/3 complex 41 (initiates actin polymerisation) |
| 3BPN:C | Interleukin-13 receptor alpha-1 chain |
| 1FLR:H | Mouse– 4-4-2- Fab fragment |
| 2W18:A | C terminal WD40 domain of human PALB2 (partner and localiser of BRCA2) |
| 2V5Y:A | Receptor protein tyrosine phosphatase |
| 2ARJ:H YTS 105.18 | Antigen binding region Heavy chain (YTS 105.18, which is commonly used in the blockade of CD8+ T-cell activation in response to peptide antigen, is specific for mouse CD8alpha) |
| 2WJS:A | Mouse—laminin subunit alpha (in basement membrane assembly and function) |
| 2R51:A | Mouse—Vacuolar protein sorting-associated protein 26B |
| 2OM5:A | Contactin 2 (neural cell adhesion)—consists of six immunoglobulin-like and four fibronectin III-like domains and is anchored to the membrane by glycosylphosphatidylinositol |
Note: The proteins highlighted in bold font indicates the human proteins in the list implicated either in inflammation or arthritic pathology.