Skip to main content
. 2017 Jan 26;12(1):e0170462. doi: 10.1371/journal.pone.0170462

Fig 1. ZIKV polyprotein processing to produce mature peptides.

Fig 1

The polyprotein of Zika virus is post-translationally processed by viral and host proteases into functional mature peptides: the capsid protein (C), intracellular capsid protein (Ci), signal peptide of the premembrane protein (pr), membrane protein (M), envelope protein (E), nonstructural proteins (NS1 –NS5), including the proteolytic helicase (NS3) and the RNA-dependent RNA polymerase (NS5), and the 2k protein (2k), whose removal activates the virus particle during its final assembly. The numbers above the mature peptides correspond to the first amino acid of each mature peptide in the full-length polyprotein for genome NC_012532.