Table 1. dPCR KRAS mutation analysis in FFPE EUS-FNA pancreas biopsy specimens.
Cytological Diagnosis | |||
---|---|---|---|
Adenocarcinoma (N = 19) | Atypical cells (N = 10) | Negative for malignancy (N = 5) | |
Age (years, SD) | 69 (10.8) | 71 (10.4) | 64 (15.6) |
Surgically resected (N, %) | 20 (100%) | 10 (100%) | 0 |
Surgical pathology diagnosis (N) | PDAC (19) |
|
N/A (no surgery) |
FFPE EUS-FNA block cellularity (N, %) [number of cells/10-um section] | |||
100–200 | 7 (31%) | 2 (22%) | 0 |
201–400 | 5 (23%) | 2 (22%) | 2 (40%) |
401–600 | 5 (23%) | 3 (33%) | 1 (20%) |
>600 | 5 (23%) | 2 (22%) | 2 (40%) |
dPCR KRAS mutation analysis (N) | |||
Mutated KRAS | 19 | 9 | 0 |
WT KRASa | 0 | 1b | 5 |
adPCR indicates absence of G12D or G12V mutation
b WT KRAS found in the patient with BD-IPMN
Abbreviations: dPCR; digital PCR, WT; wild-type, PDAC; pancreas adenocarcinoma, MD-IPM; main duct intraductal papillary mucinous neoplasm, BD-IPMN; branch duct intraductal papillary mucinous neoplasm, PanIN; pancreas intraepithelial neoplasia