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. 2017 Jan 26;12(1):e0170825. doi: 10.1371/journal.pone.0170825

Fig 8. Effects of in vivo prophylactic fingolimod on astrocytes in the spinal cord of EAE mice at the acute stage of disease.

Fig 8

On day 21 post EAE induction, tissue sections were immuno-stained with the anti-GFAP antibody (red) to recognize astrocytes and with DAPI (blue) to identify cell nuclei. (A) 10X: Low-magnification image of spinal cord sections. (B) 20X: High-magnification image of the spinal cord sections. (C) Quantitative evaluation of the number of GFAP-positive cells/Optic field in the spinal cord of mice of each treatment-group. * p < 0.05 versus all other groups; ° p < 0.05 versus untreated EAE mice.