Table 1. Prophylactic fingolimod does not modify the spontaneous release of endogenous glutamate and GABA from synaptosomes isolated from selected regions of central nervous system of EAE mice at the acute stage of disease.

	Control mice	Fingolimod-treated control mice	EAE mice	Fingolimod treated EAE mice
	endogenous glutamate (pmoles / mg protein)
cortex	123.4 ± 13.7	132.7 ± 16.0	108.4 ± 15.3	128.1 ± 15.2
hippocampus	155.9 ± 17.3	172.6 ± 22.4	182.1 ± 21.33	162.8 ± 16.3
spinal cord	198.3 ± 22.5	212.4 ± 21.3	209.7 ± 18.4	203.5 ± 22.1
	endogenous GABA (pmoles / mg protein)
cortex	83.2 ± 11.2	78.9 ± 14,5	99.5 ± 13.5	89.4 ± 16.7
hippocampus	75.4 ± 12.9	62.3 ± 9.5	71.5 ± 11.3	78.2 ± 8.3
spinal cord	65.7 ± 13.5	72.4 ± 9.1	58.4 ± 11.4	78.3 ± 14.3